SHARP is a computer program for macromolecular crystallography. It operates on reduced, merged and scaled data from SIR(AS), MIR(AS) and MAD experiments, refines the heavy-atom model, helps detect minor or disordered sites using likelihood-based residual maps, and calculates phase probability distributions for all reflections in the data set.

autoSHARP is an automated structure solution system - from merged data to automatic model building (uses SHARP as phasing engine).

Licenses Site or group licence
Categories Data analysis Crystallography Macromolecular Crystallography
Software Requirements -
Hardware Requirements -
Platforms Linux
Languages Fortran Perl Unix shell
Input Formats MTZ
Output Formats MTZ
Contact email

Instructions how to use SHARP here

In order to run autosharp:

login on the machine: (you need to be given access to it by the sysadm)

>export BDG_home=/users/sharp/sharp-2.8

>/sharp-2.8/bin/sharp/ --help

Documentation / Tutorials




SHARP reference

autoSHARP reference

Instruments ID23-1 (ESRF) ID23-2 (ESRF) ID29 (ESRF) ID30A-1 (ESRF) ID30A-3 (ESRF) ID30A-2 (ESRF) ID30B (ESRF)
No screenshots have been uploaded for this software.
This software is used at these institutes
No example datasets have been uploaded for this software.